Have you ever suffered a serious bout of sneezing and coughing when you were strolling in the garden and you were exposed to plant pollen you were allergic to. You started coughing with breathlessness when you were exposed to a dusty environment or a strong perfume.
These are all examples that you are suffering from type 1 hypersensitivity reactions or in common words sudden attack of allergy.
TYPE 1 HYPERSENSITIVITY
It is a type of immune system mediated response to a foreign particle, means some external particle when it enters our internal system,our immunity senses that it is a dangerous foreign particle though it is harmless and commonly present in our suroundings like dust,pollen,peanuts,dander animal fur,etc.
Our immune system tries to destroy it by producing eXcess of chemicals CALLED HISTAMINES. These histamine produce all the clinical conditions like nasal irritation,nasal discharge,sneezing,coughing,redness on the skin and severe itching etc
These histamine worsen our condition especially in the cold and autumn seasons.
HISTAMINES ARE RESPONSIBLE FOR ALLERGIC DERMATITIS,ALLERGIC RHINITIS,ALLERGIC CONJUCTIVITIS,ASTHMA,URTICARIA,ANGIOEDEMA MEANS ALLERGIC SWELLING OF LIPS AND FACE IN SEVERE ALLERGIC REACTIONS ETC
ATIHISTAMINES
THE FIRST ANTI HISTAMINE WAS DEVELOPED IN IN 1930S.THEY ARE THE OLDER GENERATION DRUGS WITH SIDE EFFECTS OF HIGH SEDATION ; DIPHENHYDRAMINE,PROMETHAZINE,HYDOXYZINE ,CINNARIZINE ETC.
THE SIDE EFFECTS OF OLDER GENERATION MEDS INCLUDES HIGH SEDATION,MOTOR INCORDINATION,FATIGUE,DECREASE PSYCHOMOTOR PEFORMANCE.DRYNESS OF MOUTH,URINARY HESITANCY,BLURRING OF VISION.
TO OVERCOME THESE SIDE EFFECTS
NEWER GENERATIONS WERE INTRODUCED
they are:cetrizine,levocetrizine,desloratidine,azelastine,rupatidine.
they have multi mode of actions apart from histamine blocking like inhibits release of histamine,cytotoxic mediators from platelets and eosinophils,platelet antagonistic factors and a very long duration of action so that a single dose is effective for more than 24 hrs.
These are all examples that you are suffering from type 1 hypersensitivity reactions or in common words sudden attack of allergy.
TYPE 1 HYPERSENSITIVITY
It is a type of immune system mediated response to a foreign particle, means some external particle when it enters our internal system,our immunity senses that it is a dangerous foreign particle though it is harmless and commonly present in our suroundings like dust,pollen,peanuts,dander animal fur,etc.
Our immune system tries to destroy it by producing eXcess of chemicals CALLED HISTAMINES. These histamine produce all the clinical conditions like nasal irritation,nasal discharge,sneezing,coughing,redness on the skin and severe itching etc
These histamine worsen our condition especially in the cold and autumn seasons.
HISTAMINES ARE RESPONSIBLE FOR ALLERGIC DERMATITIS,ALLERGIC RHINITIS,ALLERGIC CONJUCTIVITIS,ASTHMA,URTICARIA,ANGIOEDEMA MEANS ALLERGIC SWELLING OF LIPS AND FACE IN SEVERE ALLERGIC REACTIONS ETC
ATIHISTAMINES
THE FIRST ANTI HISTAMINE WAS DEVELOPED IN IN 1930S.THEY ARE THE OLDER GENERATION DRUGS WITH SIDE EFFECTS OF HIGH SEDATION ; DIPHENHYDRAMINE,PROMETHAZINE,HYDOXYZINE ,CINNARIZINE ETC.
THE SIDE EFFECTS OF OLDER GENERATION MEDS INCLUDES HIGH SEDATION,MOTOR INCORDINATION,FATIGUE,DECREASE PSYCHOMOTOR PEFORMANCE.DRYNESS OF MOUTH,URINARY HESITANCY,BLURRING OF VISION.
TO OVERCOME THESE SIDE EFFECTS
NEWER GENERATIONS WERE INTRODUCED
they are:cetrizine,levocetrizine,desloratidine,azelastine,rupatidine.
they have multi mode of actions apart from histamine blocking like inhibits release of histamine,cytotoxic mediators from platelets and eosinophils,platelet antagonistic factors and a very long duration of action so that a single dose is effective for more than 24 hrs.
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