latest/new/best/safe/permanent treatment for peptic/gastric/duodenal ulcer treatment/cure

DONT JUST LIVE WITH THAT HEART BURN AND INDIGESTION FOR A LONG TIME.
SEVERE ABDOMINAL PAIN AND THE REVERSE FLOW OF FOOD/GASTROESOPHAGEAL REFLEX/AND SEVERE BURNING AND IRRITATION IN THE THROAT ARE THE CLASSICAL SIGNS THAT YOU ARE SUFFERING FROM HYPERACIDITY OR PEPTIC ULCER.
DIAGNOSIS/THE TEST THAT TELLS DEFINITELY YOU HAVE PEPTIC ULCER:UPPER GI ENDOSCOPY
Its a simple test where a small tiny fibreoptic cable is passed into your stomach and abdomen thru your mouth to directly see the pesence of ulcer. its sensitivity or its ability to detect ulcer is 99%.

BEST PROVEN treatment to eradicate that ulcer for good!
Follow the following treatment with changes in life style like decreasing weight,no smoking,no alcohol,avoiding spicy and smoked foods,and doing physical exercise which helps in renewing your old and damaged body cells by new cells which gives new vigour and vitality.Miantaining a balanced diet with controlled intake of carbohydrates not more than 200 gms, adequate proteins not less than 100 gms, adequate intake of multivitamins and minerals.many a times its a half battle won.
TREATMENT AND THE DRUGS
1.PROTON PUMP INHIBITORS(PPI)
It means these are a group of meds ,which totally block the production of acid or inhibit the pumps in the body that poduce HCl. The acid content in the stomach decease by 88-95% within 4 days.
Daily dose of 40 mg pantoprazole/rabeprazole, the generic meds of ppi,taken once daily early in the morning on empty stomach without food and then having food after one hour.

2.eradication of helicobacter pylori in infection from your stomach(most important cause of peptic ulcer)
Here a combination of antibiotics are used called the triple drug regimen taken for two weeks. the regimen comprises of three medicines which together eadicate the bacteria for good.

vaRious triple drug regimens
A.amoxicillin 500 three times a day+tinidazole500 two times day+pantoprazole 40 once a day.
B.clarithromycin 500 two times a day+amoxycillin 750two times day+lansoprazole 30 once daily.
 THE ABOVE TREATMANTS ARE ENOUGH FOR YOU TO GET RID OF PEPTIC ULCER PERMANENTLY.

PEPTIC ULCER: THE MAIN/IMPORTANT/MOST COMMON CAUSE BEHIND ITS DEVELOPMENT

Peptic ulcer occurs in that pat of gastrointesinal tract which is exposed to gastric acid and a protein digesting enzyme called pepsin.
IT DEVELOPS DUE TO IMBALANCE BETWEEN THE AGRESSIVE AND DEFENSIVE FACTORS DAMAGED.
THE AGGRESSIVE FACTORS INCLUDE
1.HYDROCHLORIC ACID: the ph of HCl in our stomach is extremely low ie 2-3, that means it is highly acidic and damaging, to the lining of the stomach and small intestine.
2.PEPSIN:
A PROTEIN DIGESTING ENZYME STARTS DIGESTING INTESTINAL WALL IF THE PROTECTIVE COVER IS DAMAGED CAUSING ULCERS.
3. SMOKING
smoking plays a havoc in development of peptic ulcers
4.CHRONIC STRESS
people who are chronically stressed are commonly affected with this disease.
5.Obesity
obesity causes the reflux of food back from small intestine to stomach,therefore exposing to more acid
6.Alcohol consumption
7.regular intake of spicy foods
8.HELICOBACTER PYLORI INFECTION
Now considered to be the most notorius and important factor in the development of peptic ulcer. Helicobacter pylori is commonly found in the stomach lining of patients suffering from chronic ulcers.
Its eradication from the intestine is etremely difficult and involves the intake of 3-4 antibiotics and PPIs i.e.antiacidity medicine.
DEFENSIVE CAUSES
GASTRIC MUCOSA; gastric ulcer mucosa is caused derceased gastric mucus formation due to prostaglandins.
DECREASED RESISTANCE TO BACTERIA ,BODYS IMMUNITY ALSO PLAYS A GOOD PART IN APLLICATION DUE TO DECREASED R ESISTANCE.
O,BLOOD GROUP IS COMMONLY KNOWN TO BE ASSOCIATED WITH GASTRIC ULCERS

HISTAMINE AND ANTIHISTAMINES :WHAT ARE THEY/BEST/LATEST/ ANTI HISTAMINES/BEST TREATMENT FOR ALLERGIC RHINITIS/DERMATITIS

Have you ever suffered a serious bout of sneezing and coughing when you were strolling in the garden and you were exposed to plant pollen you were allergic to. You started coughing with breathlessness when you were exposed to a dusty environment or a strong perfume.
These are all examples that you are suffering from type 1 hypersensitivity reactions or in common words sudden attack of allergy.
TYPE 1 HYPERSENSITIVITY
It is a type of immune system mediated response to a foreign particle, means some external particle when it enters our internal system,our immunity senses that it is a dangerous foreign particle though it is harmless and commonly present in our suroundings like dust,pollen,peanuts,dander animal fur,etc.
Our immune system tries to destroy it by producing eXcess of chemicals CALLED HISTAMINES. These histamine produce all the clinical conditions like nasal irritation,nasal discharge,sneezing,coughing,redness on the skin and severe itching etc

These histamine worsen our condition especially in the cold  and autumn seasons.
HISTAMINES ARE RESPONSIBLE FOR ALLERGIC DERMATITIS,ALLERGIC RHINITIS,ALLERGIC CONJUCTIVITIS,ASTHMA,URTICARIA,ANGIOEDEMA MEANS ALLERGIC SWELLING OF LIPS AND FACE IN SEVERE ALLERGIC REACTIONS ETC

ATIHISTAMINES
 THE FIRST ANTI HISTAMINE WAS DEVELOPED IN IN 1930S.THEY ARE THE OLDER GENERATION DRUGS WITH SIDE EFFECTS OF HIGH SEDATION ; DIPHENHYDRAMINE,PROMETHAZINE,HYDOXYZINE ,CINNARIZINE ETC.
THE SIDE EFFECTS OF OLDER GENERATION MEDS INCLUDES HIGH SEDATION,MOTOR INCORDINATION,FATIGUE,DECREASE PSYCHOMOTOR PEFORMANCE.DRYNESS OF MOUTH,URINARY HESITANCY,BLURRING OF VISION.
TO OVERCOME THESE SIDE EFFECTS
NEWER GENERATIONS WERE INTRODUCED
they are:cetrizine,levocetrizine,desloratidine,azelastine,rupatidine.
they have multi mode of actions apart from histamine blocking like inhibits release of histamine,cytotoxic mediators from platelets and eosinophils,platelet antagonistic factors and a very long duration of action so that a single dose is effective for more than 24 hrs.

HYGIENE/CLEANLINESS TO BE FOLLOWED IN TREATMENT/PREVENTION/RECURRENCE OF ACNE VULGARIS/PIMPLES/ON FACE

TO KEEP THE BACTERIAL COUNT AS LOW AS POSSIBLE ON THE SKIN YOU HAVE TO ELIMINATE THOSE HOUSEHOLD SOURCES RESPONSIBLE FOR THE TRANSMISSION OF BACTERIA. THEY INCLUDE THE FOLLOWING:

1.TOWELS FOR WIPING THE FACE. THEY ARE THE BIGGEST HARVESTORS OF BACTERIA WHICH EASILY GETS TRANSMITTED TO YOUR FACE IF YOU USE IT AGAIN AND AGAIN WITHOUT WASHING OR SHARING IT WITH SOMEONE ELSE.
HERE YOU HAVE TO REMEMBER TO USE EITHER USE AND THROW FACIAL WIPES OR USE A NEW WASHED TOWEL NAPKINS FOR EACH DAY.

2. ALWAYS WASH YOUR HAIR AND KEEP IT FREE FROM OILINESS CAUSES THEY ARE THE EASIEST SOURCE OF BACTERIA SPREADING FROM SCALP TO FACE.

3.ALWAYS WASH YOUR PILLOW COVER EVERY DAY OR USE A NEW ONE EVERYDAY CAUSE IT EASILY COLLECTS BACTERIA FROM BOTH YOUR FACE AND HAIR WHILE SLEEPING.

4.NEVER PICK THE SKIN. ITS THE MOST IRRESISTBLE THING TO DO. IF YOU KEEP THE HABIT OF TOUCHING THE FACE THEN YOU ARE DIRECTLY INTRODUCING BACTERIA TO YOUR SKIN.

5. DISINFECT THE HOUSEHOLD FURNITURE REGULARY,TABLES,COMPUTERS,THEIR KEYBOARS LIKE YOUR DOOR HANDLES,CHAIRS,SOFA SETS,ALL THOSE ITEMS WHICH YOU REGULARLY USE.

6.KEEP YOUR CELLPHONES AWAY FROM YOUR FACE WHILE TALKING.THEY ARE COMMONLY USED AND CONTAINS A LOT OF GERMS IF NOT DISINFECTED REGULARLY.

MICRO ORGANISMS/GERMS/CAUSES/ RESPONSIBLE FOR /CAUSE/DEVELOPMENT/PATHOGENESIS OF ACNE/PIMPLES/ZITS

1.STAPHYLOCOCCUS EPIDERMIDIS
Its a common commensal or friendly bacteria found on our skin.
It is a gram positive , bacteria present in chains. They are very difficult to eradicate from the skin. they dont normally cause infection but they colonise the hair follicles due to the presence of excessive sebum.

2.PROPIONIBACTERIUM ACNES
ITA A GRAM NEGATIVE ANAEROBIC BACTERIA COMMONLY PRESENT IN THE PILOSEBAECEOUS UNITS.
THEY CAUSE THE INFECTION THE SAME WAY STAPHYLOCOCCUS DOES.
Benzoyl peroxide is the best topical treatment against it.

3.Pityosporum ovale

A Fungal infection is also associted to cause acne. A treatment of ketoconazole and zinc pyrithione is very effective to get rid of that fungal infection.

BEST/LATEST/EASY/MANAGEMENT OF ACNE/PIMPLES/ZITS/

ANTIBIOTICS

TOPICAL: erythromycin or clindamycin, NADIFLOXACIN gel applied to the skin after washing the face from mild antibacterial soap.Apply before sleeping at night for its good effect.

ORAL: Oxytetracycline taken on empty stomach without food in a dose upto 1.5 grams daily in a day in two divided doses.

BENZOYL PEROXIDE 0.5 AND 1% GEL

It is the cornerstone in the treatment of acne. It kills the bacteria by releasing oxidants which kill and decrease the baterial population. It also a keratolytic which helps in removing the dead cells and opening the pores.Its dries the oil in the follicles which indirectly decreases  bacterial population. due to its multimodality of action its the most peferred teatment in the acne.

Dosage: a small quantity should be applied after washing face by a mild soap. keep the cream for 20-30 minutes and wash off. Initially it will give a tingling and burning sensation but it goes off soon. Should be avoided if severe rashes occur on the face.

WOMENS SPECIFIC TREATMENT

Oral contraceptive pills and anti androgens like cyproterone acetate are very effective  and given to only women.

Adapalene Topical Gel

Its acts on retinoind receptos and promotes follicular diffrentiation. it has very good anti inflammatory effects.

ISOTRETINOIN

THIS IS THE MEDICINE THAT REVOLUTIONISED THE TREATMENT OF ACNE.

SEVERE OR MODERATE UNRESPONSIVE TO TRADITIONAL TREARMENT IS TAKEN IN THE DOSE OF 0-5 TO 1 MG/KG.

MECHANISM OF ACTION: IT A GOLD STANDARD FOR DECREASING OIL PRODUCTION.

IT ALSO PROMOTES KERAEATINISATOION.IT CAUSES DRY SKIN . BECAUSE OF ITS OIL DECREASING EFFECT THE OIL GLAND  GETS DRIED UP INDIECTLY DECREASE THE BACTERIAL POPULATION

A TREATMENT COURSE OF ATLEST 14 MONTHS IS REQUIRED.

IT IS STRICTLY PROHIBITED IN PREGNANT WOMEN BECAUSE OF ITS SIDE EFFECT OF TERATOGENICITY CAUSE BIRTH DEFECTS IN NEW BORNS

OTHER VARIANTS/TYPES OF ACNE/PIMPLES

VARIANTS OR OTHER FORMS OF ACNE

1. Conglobate acne:
Its characterised by nodules,abcesses,sinus tracks often accompanied by keloid scarring although true cysts are are in acute cases and are more likely to be present in inflammatory nodules. Epidermoid cysts are common later on in acne.

2.Acne fulminans:
severe acne accompanied by fever and joint pains and markers of systemic inflammation such as raised ESR.

3.Acnee excoree
Refers to the effects of scratcing or picking principally on the face of teenage girls with acne.

4.Chemical causes
Tars,chlorinated hydrocarbons or oily cosmetics are also the causes.

5.Medications side effects
a .corticosterids: these meds are commonly pescribed in allergic conditions asthma,psoriasis, inflammatory joint and bone pains,rheumatoid artritis,osteoarthritis,rheumatic fever,gout,SLE,urticaria,angioneurotic edema,anaphylaxis,autoimmune hemolytic anemia,idiopathic thrombocytopenic purpura,allergic conjuctivitis ,irtis,iridocyclitis,ulcerative disease,chrons disease ,malignancies like acute lymphatic leukemia,hodgkins lymphoma to name a few. this medicine is so frequently prescribed that it has become the backbone of medicine.
b. lithium: commonly used in teatment of psychiatirc disorder called bipolar disorder,unipolar depression,chronic mania
c. Oral contraceptive pills: have become a very common cause among the medicines
d. anticonvulsants like phenytoin and carbamazepine are notorious for their acne inducing side effects.

6.Pregnancy induced acne is seen in pregnant women due to their high fluctuations of gonadal hormones .
7.Adult acne
Seen in adults mostly in 30-40 yrs of age who have never experienced acne in teenage.